"Rohde and colleagues investigated how cardiovascular disorders can affect haematopoiesis by influencing the vascular endothelial cells that line the blood vessels in the bone marrow. The authors found that, compared with healthy control individuals, individuals with hypertension (high blood pressure), people with hypertension and atherosclerosis, or those who had recently had an acute myocardial infarction, all showed increased haematopoiesis and, more specifically, increased numbers of myeloid immune cells derived from a subtype of Haemotopoietic Stem and Progenitor Cells called myeloid progenitor cells.
They then examined haematopoiesis in three different mouse models of hypertension, which is a risk factor for severe types of cardiovascular disease, such as atherosclerosis and myocardial infarction. All hypertensive mice showed increased haematopoiesis and myelopoiesis (the proliferation and differentiation of myeloid progenitor cells), indicating that changes in haematopoiesis can not only precede, but also result from, cardiovascular disease." [1]
1. Nature 601, 515-517 (2022)
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