Stanford President Resigns After Probe.

"Stanford University President Marc Tessier-Lavigne is resigning, saying the failures highlighted in a recent review by a panel of top scientists could raise questions about his ability to continue leading the school.

The panel, which issued its report Wednesday, found no evidence that Tessier-Lavigne personally engaged in research misconduct, or that he knew of misconduct by others, but determined that data were manipulated in some published scientific papers on which he was a main contributor. The group also said he failed to decisively correct mistakes in published papers as they were uncovered and had lapses in oversight of his labs at multiple institutions.

Stanford launched an investigation into Tessier-Lavigne late last fall, after the student newspaper published an article alleging that images were altered in at least four research papers to which he contributed. The accusations raised concerns about the academic integrity of the leader of one of the world's most prestigious research institutions. Tessier-Lavigne, a neuroscientist, has conducted research focused on degenerative brain diseases and therapies for spinal-cord injuries.

He will step down at the end of August.

"As I have emphatically stated, I have never submitted a scientific paper without firmly believing that the data were correct and accurately presented," Tessier-Lavigne wrote in a letter Wednesday announcing his resignation. "I expect there may be ongoing discussion about the report and its conclusions, at least in the near term, which could lead to debate about my ability to lead the University into the new academic year."

Stanford's board of trustees convened a special committee in December, which in turn established a panel of scientists in January to assist in the investigation. The investigation was led by Mark Filip, a former federal judge, and a team at the law firm Kirkland & Ellis, where he is a partner.

The five-member scientific panel included renowned neuroscientists, a Nobel laureate and a former Princeton University president. The panel and Kirkland & Ellis reviewed more than 50,000 documents, including lab data and correspondence, received assistance from forensic image analysts and communicated with scientific journals, according to a copy of the report released Wednesday.

The panel ultimately studied 12 published papers. They found that for the seven on which Tessier-Lavigne wasn't a primary contributor, he didn't have a material role in preparing the data or resultant images, and wouldn't have been in a position to catch any misconduct.

However, they said, there were "serious flaws" in how the research data was presented in the five papers on which he was the lead author, and there was evidence of data manipulation by others in at least four of them. 

Tessier-Lavigne said he would retract three papers, published in the journals Cell and Science in 1999 and 2001, respectively, and issue corrections on the other two, published in Nature in 2004 and 2009.

In December, both Cell and Science issued formal editorial expressions of concern on the papers that are now being retracted, while Nature wrote in March that it was investigating concerns about the 2009 paper. In April, the EMBO Journal, a European scientific publication, retracted some figures and corrected or updated others from a 2008 paper.

Holden Thorp, editor in chief of Science, said Tessier-Lavigne asked him Wednesday morning to retract the papers, and the notices of retraction should replace the expressions of editorial concern within the next week or two. A Cell representative said retractions are dealt with as quickly as possible, but can take up to a few weeks or months to finalize. A representative from Nature couldn't be reached for comment.

The scientific panel convened by Stanford determined that when concerns about some of the data arose -- in 2001, the early 2010s, 2015-2016 and March 2021 -- Tessier-Lavigne didn't do enough to correct the record.

Tessier-Lavigne said he notified editors at Cell and Science of errors in the papers in 2015, but the team at Cell determined it didn't need to publish a correction at the time and Science never published the corrections he provided. He should have pushed harder, the panel said.

"I agree that in some instances I should have been more diligent when seeking corrections, and I regret that I was not," Tessier-Lavigne said in his letter Wednesday. "The Panel's review also identified instances of manipulation of research data by others in my lab. Although I was unaware of these issues, I want to be clear that I take responsibility for the work of my lab members."

The panel concluded that while there were many positive attributes to the culture in Tessier-Lavigne's research labs, "the unusual frequency of manipulation of research data and/or substandard scientific practices from different people, at different times, and in labs at different institutions, suggests that there may have been opportunities to improve laboratory oversight and management."

Scientists increasingly work in large teams, dispersed across multiple campuses. The senior researcher pulls together their work and bears the ultimate responsibility for the information being published; scientists say they must put a lot of trust in their collaborators to maintain high standards of research.

Tessier-Lavigne said he would remain on the Stanford faculty and continue his research on neurodegeneration. Richard Saller, chair of the classics department and former dean of Stanford's School of Humanities and Sciences, will take over as interim president on Sept. 1. Tessier-Lavigne has been president of Stanford since 2016." [1]

The main problem is a combination of high flying boss and almost slaves who do all the work. The competition in such high profile labs is vicious. There are no established work hours. There is no collaboration and friendship. Publish or perish is at the extreme. This ruins some people.

1. Stanford President Resigns After Probe. Korn, Melissa; Marcus, Amy Dockser. 
Wall Street Journal, Eastern edition; New York, N.Y. [New York, N.Y]. 20 July 2023: A.1.