"Faced with a new
sequence, it first looks for related sequences
in databases, which can identify amino acids
that have tended to evolve together, suggesting they’re close in 3D space. The structure of existing related proteins provides another way to estimate distances between amino-acid pairs in the new sequence.
AlphaFold iterates clues from these parallel
tracks back and forth as it tries to model the 3D positions of amino acids, continually updating its estimate." [1]
From this description, it is clear why this software cannot predict, at least not yet, how the structure of a protein will change with a cancer-causing mutation - because no data are available for such an analysis.
1. WHAT’S NEXT FOR
THE AI PROTEIN FOLDING
REVOLUTION
AlphaFold, software that can predict the 3D
shape of proteins, is already changing biology.
By Ewen Callaway, Nature | Vol 604 | 14 April 2022
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